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Magnesium is essential for overall well-being, supporting everything from muscle function to better sleep. But when is the best time to take it—on an empty stomach or with food? While both options are possible, taking magnesium with food is generally recommended. It not only improves absorption but also helps prevent digestive side effects like nausea and stomach cramps. Although some people prefer the faster absorption that comes with taking magnesium on an empty stomach, this method carries a higher risk of discomfort. For most, pairing magnesium with a meal ensures a smoother, more effective experience.